Treatment of Leptomeningeal Metastases Evaluated by Interphase Cytogenetics

Treatment of leptomeningeal metastases evaluated by interphase cytogenetics.

PURPOSE Although cytologic examination of CSF is the primary method for the evaluation of response to therapy for leptomeningeal metastases (LMMs), the procedure's sensitivity decreases throughout the course of protracted therapy. We studied whether this response could be monitored more accurately through the detection of numerical chromosomal aberrations by interphase cytogenetics, using fluor...

Treatment modalities for leptomeningeal metastases.

Secondary involvement of the leptomeninges represents an infrequent but devastating (and nearly always fatal) complication of solid tumors, hematologic malignancies (both leukemia and lymphoma), and primary brain tumors. Clinical suspicion of neoplastic meningitis (NM) may be raised by the appearance of multivariate neurological symptoms; however, a definitive diagnosis is often difficult to ob...

LEPTOMENINGEAL METASTASES Cancer Treatment and Research

Leptomeningeal Metastases

1. Carcinomatous meningitis (metastases caused by carcinoma such as lung and breast) 2. Meningeal gliomatosis (dissemination of CSF caused by malignant glial tumors) 3. Leptomeningeal metastases secondary to other underlying solid tumors (e.g., rhabdomyosarcoma, neuroblastoma, medulloblastoma, other primitive neuroectodermal tumors) 4. Lymphomatous meningitis (metastases caused by lymphoma) 5. ...

Interphase cytogenetics of workers exposed to benzene.

Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. In previous studies, FISH has been used to demonstrate that the benzene metabolites hydroquinone and 1,2,4-benzenetriol induce aneuploidy of chromosomes 7 and 9 in cultures of human cells. In the present study, we used an interphase ...